Эпидемиология, этиология и патогенез эозинофильного эзофагита. Новейшие данные

Авторы:
  • В. О. Кайбышева
    ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова», Москва, Россия
  • Л. М. Михалева
    ФГБНУ «Научно-исследовательский институт морфологии человека», Москва, Россия
  • Е. Л. Никонов
    ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова», Москва, Россия
  • С. Г. Шаповальянц
    ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова», Москва, Россия
Журнал: Доказательная гастроэнтерология. 2019;8(2): 50-72
Просмотрено: 2953 Скачано: 775

Цель исследования — представить современные взгляды на эпидемиологию, этиологию, патогенез эозинофильного эзофагита (ЭоЭ). Основные положения. Эозинофильный эзофагит — недостаточно изученное заболевание пищевода, в основе патогенеза которого лежит предрасположеность к развитию иммунного ответа по пути активации Т-хелперов 2-го типа, экспрессирующих при контакте с экзогенными аллергенами чрезвычайно активную группу цитокинов. Высокая концентрация Тh2-цитокинов в слизистой оболочке пищевода приводит к эозинофильной инфильтрации стенки пищевода на всем его протяжении (от проксимального до дистального отдела), развитию хронического воспаления в толще эпителия и собственной пластинки слизистой оболочки пищевода, развитию подслизистого фиброза. Выводы. ЭоЭ — это хроническое Th2-ассоциированное заболевание пищевода, характеризующееся развитием выраженного эозинофильного воспаления в слизистой оболочке пищевода и подслизистого фиброза, клинически проявляющееся дисфункцией пищевода (затруднения при приеме пищи у детей — рвота, поперхивание, отказ от еды и дисфагия у подростков и взрослых).

Ключевые слова:
  • эозинофильный эзофагит
  • эозинофилия пищевода
  • Т-хелперы 2-го типа
  • дисфагия

КАК ЦИТИРОВАТЬ:

Кайбышева В.О., Михалева Л.М., Никонов Е.Л., Шаповальянц С.Г. Эпидемиология, этиология и патогенез эозинофильного эзофагита. Новейшие данные. Доказательная гастроэнтерология. 2019;8(2):50-72. https://doi.org/10.17116/dokgastro2019802150

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