Lipoprotein(a) and triglyceride-rich lipoproteins — association with recurrent nonfatal myocardial infarction in patients with early manifestation of coronary artery disease

O.I. Afanasieva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-8909-8662

T.I. Arefieva

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

ORCID: 0000-0002-9500-1940

A.V. Tyurina

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0003-3505-2487

A.Yu. Filatova

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-8911-1628

O.A. Razova

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-1132-2529

E.A. Klesareva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0682-8699

N.V. Radyukhina

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-2473-061X

N.Yu. Ruleva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-9005-7718

M.V. Ezhov

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-1518-6552

S.N. Pokrovsky

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-5105-0313

Lipoprotein(a) and triglyceride-rich lipoproteins — association with recurrent nonfatal myocardial infarction in patients with early manifestation of coronary artery disease

Authors:

O.I. Afanasieva, T.I. Arefieva, A.V. Tyurina, A.Yu. Filatova, O.A. Razova, E.A. Klesareva, N.V. Radyukhina, N.Yu. Ruleva, M.V. Ezhov, S.N. Pokrovsky

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Journal: Russian Cardiology Bulletin. 2024;19(1): 29‑37

DOI: 10.17116/Cardiobulletin20241901129

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Afanasieva OI, Arefieva TI, Tyurina AV, Filatova AYu, Razova OA, Klesareva EA, Radyukhina NV, Ruleva NYu, Ezhov MV, Pokrovsky SN. Lipoprotein(a) and triglyceride-rich lipoproteins — association with recurrent nonfatal myocardial infarction in patients with early manifestation of coronary artery disease. Russian Cardiology Bulletin. 2024;19(1):29‑37. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241901129

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Elevated serum lipoprotein(a) is associated with early manifestation of coronary artery disease and higher risk of acute cardiovascular events including myocardial infarction. Neutrophil granulocyte activation leading to cell death is accompanied by release of various inflammatory and thrombotic mediators. These substances cause atherosclerotic plaque destabilization. In this study, we have shown that netosis in primary culture of neutrophils is stimulated by lipoprotein(a) rather triglyceride-rich lipoproteins. We found a correlation between lipoprotein (a) and neutrophil elastase content in homogenates of human coronary artery atherosclerotic plaques. In patients with early manifestation of coronary artery disease and lipoprotein(a) >30 mg/dL, the content of circulating neutrophils correlated with remnant cholesterol as a component of triglyceride-rich lipoproteins. Hyperlipoproteinemia(a) and low-molecular-weight apolipoprotein(a) phenotype independently increased the risk of recurrent myocardial infarction. This risk was maximal in case of additional elevation of remnant cholesterol. These data suggest that triglyceride-rich lipoproteins accompanied by hyperlipoproteinemia(a) and low-molecular-weight apo(a) phenotype contribute to aggravation of inflammatory process in the vascular wall via stimulation of leukocyte recruitment.

Keywords:

lipoprotein(a)

triglyceride-rich lipoproteins

neutrophil granulocytes

atherosclerosis

myocardial infarction

Authors:

O.I. Afanasieva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-8909-8662

T.I. Arefieva

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

ORCID: 0000-0002-9500-1940

A.V. Tyurina

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0003-3505-2487

A.Yu. Filatova

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-8911-1628

O.A. Razova

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-1132-2529

E.A. Klesareva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0682-8699

N.V. Radyukhina

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-2473-061X

N.Yu. Ruleva

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-9005-7718

M.V. Ezhov

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-1518-6552

S.N. Pokrovsky

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-5105-0313

Received:

17.11.2023

Accepted:

23.11.2023

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