Гесперидин: потенциальные, но недооцененные возможности

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Гесперидин представляет собой флавоноид, присутствующий в высокой концентрации в цитрусовых и обладающий многочисленными биологическими свойствами, главным образом антиоксидантными и противовоспалительными. Было проведено несколько исследований с целью оценки эффектов гесперидина как противовоспалительного средства с использованием клеточных, животных моделей и нескольких клинических испытаний. Лечение гесперидином уменьшало количество медиаторов воспаления и оказывало значительный антиоксидантный эффект. Несмотря на то что гесперидин продемонстрировал противовоспалительный эффект, конкретный механизм его действия до конца неизвестен, и для выяснения молекулярных мишеней необходимы дополнительные исследования. Интересным для дальнейшего изучения является эффективность гесперидина в отношении предотвращения набора массы тела и уменьшения площади висцерального жира. Комбинация, содержащая два флавоноида в стандартизированных дозировках (10% гесперидина + 90% диосмина), обладает выраженным антиоксидантным, противовоспалительным и венотонизирующим эффектом: уменьшает повреждение и активацию эндотелия и адгезию лейкоцитов, сохраняет целостность капилляров, улучшает венозный тонус, уменьшает выраженность симптомов хронического заболевания вен и тем самым улучшает качество жизни больных. Стандартизация дозировок компонентов, входящих в состав комбинации, делает эти эффекты более предсказуемыми.

Ключевые слова:

варикозная болезнь

хроническое заболевание вен

флеботропные препараты

стандартизированные дозировки

флавоноиды

гесперидин

Авторы:

Головина В.И.

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России

SPIN РИНЦ: 9731-8542
Scopus AuthorID: 57215120242
ORCID: 0000-0002-8719-7154

Панфилов В.А.

SPIN РИНЦ: 8249-7989
ORCID: 0000-0001-5186-5459

Золотухин И.А.

SPIN РИНЦ: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Дата поступления:

09.11.2023

Дата принятия в печать:

19.11.2023

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