BACKGROUND
The necessity of searching for new techniques of ventroplasty of the anterior abdominal wall, as well as the development and introduction of surgical mesh implants, is associated with the improvement of the effectiveness of treatment of patients with post-surgery ventral hernias.
OBJECTIVE
To carry out the comparative evaluation of the results of prosthetic ventroplasty with synthetic and biological materials in experiment and clinic.
MATERIAL AND METHODS
To achieve the set goal, ventroplasty was performed on biological models by using the following techniques: onlay, inlay and sublay. Laboratory animals — rabbits weighing 2000±50 g and rats weighing 400±50 g were used as experimental models. Surgical mesh implants were used as implantation material: Prolene and Reperen. Fixation was carried out by using continuous sutures. On the 21st day of the experiment the material was taken for the study of its biomechanical and morphological properties. The morphological properties were assessed by histological methods of staining the preparation: hematoxlin-eosin and Van Gieson’s picrofuchsin staining; the biomechanical properties were assessed on the tearing machine Instron 5944.
RESULTS
During the comparison of the indices of the biomechanical properties of the abdominal wall with the maximum value of load (N), stress (MPa), and Young’s modulus the dependence of the biomechanical and morphological properties of the prosthetic ventroplasty on the technique of sublayering of the mesh implant was confirmed. Furthermore, the advantages of the separation ventroplasty using the sublayering technique were substantiated.
CONCLUSION
On the basis of the results of biomechanical and morphological research the compatibility of biological implants and tissues of the anterior abdominal wall was proven. For the first time in the experiment on rabbits the comparative evaluation of the peculiarities of integration of the selected surgical mesh materials was carried out. During the experiment the dependence of biomechanical and morphological properties of prosthetic ventroplasty on the used technique of mesh implant suturing was confirmed and the advantages of separative ventroplasty by sublay technology were substantiated.
