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Gorozhanin A.V.

Botkin Moscow City Clinical Hospital

Kuzin A.V.

Russian Medical Academy of Continuous Professional Education;
A.V. Nassonova Research Institute of Rheumatology

Bludov A.B.

Blokhin Russian Cancer Research Center

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

Kuzin D.A.

Sechenov First Moscow State Medical University

Krylov A.S.

Blokhin Russian Cancer Research Center

Severe spine lesion following alkaptonuria. Case report

Authors:

Gorozhanin A.V., Kuzin A.V., Bludov A.B., Radenska-Lopovok S.G., Smirnov A.V., Kuzin D.A., Krylov A.S.

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Journal: Burdenko's Journal of Neurosurgery. 2021;85(5): 104‑109

DOI: 10.17116/neiro202185051104

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To cite this article:

Gorozhanin AV, Kuzin AV, Bludov AB, Radenska-Lopovok SG, Smirnov AV, Kuzin DA, Krylov AS. Severe spine lesion following alkaptonuria. Case report. Burdenko's Journal of Neurosurgery. 2021;85(5):104‑109. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202185051104

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
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Alkaptonuria is a rare autosomal recessive disease. In these patients, melanin-like compounds as the final products of impaired metabolism of homogentisic acid are deposited mainly in connective tissue, including cartilage tissue of intervertebral discs. Similar to other degenerative spine diseases, lumbar segment is often damaged. The authors report a 67-year-old patient with alkaptonuria. Compression of cauda equina by damaged cartilage masses of intervertebral discs and spine ligaments with deposits of ochronotic pigment is described. Previously diagnosed alkaptonuria in this patient was confirmed by surgical findings (black pigmentation) and histological data.

Keywords:

alkaptonuria
ochronosis
back pain

Authors:

Gorozhanin A.V.

Botkin Moscow City Clinical Hospital

Kuzin A.V.

Russian Medical Academy of Continuous Professional Education;
A.V. Nassonova Research Institute of Rheumatology

Bludov A.B.

Blokhin Russian Cancer Research Center

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

Kuzin D.A.

Sechenov First Moscow State Medical University

Krylov A.S.

Blokhin Russian Cancer Research Center

Received:

14.01.2021

Accepted:

05.08.2021

List of references:

  1. Phornphutkul C, Introne WJ, Perry MB, Bernardini I, Murphey MD, Fitzpatrick DL, Anderson PD, Huizing M, Anikster Y, Gerber LH, Gahl WA. Natural history of alkaptonuria. The New England Journal of Medicine. 2002;347(26):2111-2121. https://doi.org/10.1056/NEJMoa021736
  2. Zatkova A. An update on molecular genetics of Alkaptonuria (AKU). Journal of Inherited Metabolic Disease. 2011;34(6):1127-1136. https://doi.org/10.1007/s10545-011-9363-z
  3. Ranganath LR, Jarvis JC, Gallagher JA. Recent advances in management of alkaptonuria (invited review; best practice article). Journal of Clinical Pathology. 2013;66(5):367-373.  https://doi.org/10.1136/jclinpath-2012-200877
  4. Rohrbach JM, Röck D. Ocular Ochronosis. Deutsches Arzteblatt International. 2018;115(16):286.  https://doi.org/10.3238/arztebl.2018.0286a
  5. Taylor AM, Wlodarski B, Prior IA, Wilson PJ, Jarvis JC, Ranganath LR, Gallagher JA. Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment. Rheumatology. 2010;49(7):1412-1414. https://doi.org/10.1093/rheumatology/keq027
  6. Pierce TP, Issa K, Ramirez A, Sclafani S, Harwin SF, Scillia AJ, Rifai A, McInerney VK. Ochronosis as Etiology of Requiring Total Knee Arthroplasty-A Case Series. Surgical Technology International. 2016;29:261-264. 
  7. Alrawashdeh O, Alsbou M, Alzoubi H, Al-Shagahin H. Neurological Assessment and Nerve Conduction Study Findings in 22 Patients with Alkaptonuria from Jordan. Neurology International. 2017;8(4):6841. https://doi.org/10.4081/ni.2016.6841
  8. Pathak SK, Kumar N, Bagtharia P. Alkaptonuria and multilevel intervertebral disc calcification. Joint Bone Spine. 2020;87(3):259.  https://doi.org/10.1016/j.jbspin.2020.01.004
  9. Reddy DR, Prasad VS. Alkaptonuria presenting as lumbar disc prolapse: case report and review of literature. Spinal Cord. 1998;36(7):523-524.  https://doi.org/10.1038/sj.sc.3100562
  10. Emel E, Karagöz F, Aydín IH, Hacísalihoğlu S, Seyithanoğlu MH. Alkaptonuria with lumbar disc herniation: a report of two cases. Spine. 2000;25(16):2141-2144. https://doi.org/10.1097/00007632-200008150-00021
  11. Choudhury R, Rajamani SS, Rajshekhar V. A case of ochronosis: MRI of the lumbar spine. Neuroradiology. 2000;42(12):905-907.  https://doi.org/10.1007/s002340000428
  12. Farzannia A, Shokouhi G, Hadidchi S. Alkaptonuria and lumbar disc herniation. Report of three cases. Journal of Neurosurgery. 2003;98(1 suppl):87-89.  https://doi.org/10.3171/spi.2003.98.1.0087
  13. Gürkanlar D, Daneyemez M, Solmaz I, Temiz C. Ochronosis and lumbar disc herniation. Acta Neurochirurgica. 2006;148(8):891-894.  https://doi.org/10.1007/s00701-006-0774-9
  14. Mirzashahi B, Tafakhori A, Najafi A, Farzan M. Neglected Alkaptonuric Patient Presenting with Steppage Gait. The Archives of Bone and Joint Surgery. 2016;4(2):188-191. 
  15. Kahveci R, Ergüngör MF, Günaydin A, Temiz A. Alkaptonuric patient presenting with «black» disc: a case report. Acta Orthopaedica et Traumatologica Turcica. 2013;47(2):134-138.  https://doi.org/10.3944/aott.2013.2767
  16. Yucetas SC, Ucler N. Black-Colored Ligamentum Flavum Due to Alkaptonuria. Journal of Neurological Surgery. Part A, Central European Neurosurgery. 2019;80(2):131-133.  https://doi.org/10.1055/s-0038-1675784
  17. Gushcha AO, Yusupova AR. Modern concepts of intervertebral disc degeneration. Voprosy nejrohirurgii im. N.N. Burdenko. 2020;84(6):112-117. (In Russ.). https://doi.org/10.17116/neiro202084061112
  18. Millucci L, Bernardini G, Spreafico A, Orlandini M, Braconi D, Laschi M, Geminiani M, Lupetti P, Giorgetti G, Viti C, Frediani B, Marzocchi B, Santucci A. Histological and Ultrastructural Characterization of Alkaptonuric Tissues. Calcified Tissue International. 2017;101(1):50-64.  https://doi.org/10.1007/s00223-017-0260-9

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