Recovery of consciousness under therapy with benzodiazepines. A case report and literature review

Belousova OB, Konovalov AN, Savin IA, et al. . Recovery of consciousness under therapy with benzodiazepines. A case report and literature review. Burdenko's Journal of Neurosurgery. 2024;88(3):81‑89. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20248803181

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)

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BACKGROUND

Treatment of patients with prolonged and permanent disturbance of consciousness is still an extremely difficult problem. Nowadays, management is based on pathophysiological and molecular mechanisms of impaired consciousness. Several electrophysiological and pharmacological methods were proposed to restore consciousness in appropriate patients.

OBJECTIVE

We present recovery of clear consciousness under therapy with phenazepam and literature review devoted to therapy of these disorders.

RESULTS AND CONCLUSION

This case confirms available data on drug neuromodulation in complex treatment of patients with prolonged impairment of consciousness and substantiates the need for individual multimodal assessment of structural and functional disorders in prolonged and chronic impairment of consciousness for adequate therapy.

Keywords:

prolonged impairment of consciousness

chronic impairment of consciousness

neuromodulation

neurotransmitters

benzodiazepines

Authors:

Belousova O.B.

Burdenko Neurosurgical Center

ORCID: 0000-0003-4908-8923

Konovalov A.N.

Burdenko Neurosurgical Center

SPIN RSCI: 1462-1783
Scopus AuthorID: 57220527356
ORCID: 0000-0002-5048-0298

Savin I.A.

Burdenko Neurosurgical Center

ORCID: 0000-0003-2594-5441

Birg T.M.

Burdenko Neurosurgical Center

ORCID: 0000-0001-5935-1233

Lapteva K.N.

Burdenko Neurosurgical Center

ORCID: 0000-0003-1163-7253

Pitskhelauri D.I.

Burdenko Neurosurgical Center

SPIN RSCI: 3261-2144
Scopus AuthorID: 6507820245
ORCID: 0000-0003-0374-7970

Kadyrov Sh.U.

Burdenko Neurosurgical Center

RSCI AuthorID: 669386
Scopus AuthorID: 23473552800
ORCID: 0000-0001-5879-1333

Sidneva Yu.G.

Burdenko Neurosurgical Center

ORCID: 0000-0003-2733-5874

Khukhlaeva E.A.

Burdenko Neurosurgical Center

ORCID: 0000-0003-2424-5582

Received:

14.02.2024

Accepted:

22.03.2024

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