The neomod scale in predicting the outcomes in newborns with birth weight less than 1500 grams: a retrospective cohort study

To analyze the relationship between high and low NEOMOD scores, medical records, clinical characteristics and outcomes in preterm infants with gestational age <32 weeks and birth weight <1500 grams in early neonatal period.

MATERIAL AND METHODS

A retrospective observational cohort single-center study included 78 premature newborns between 2022 and 2023. All ones were divided into two groups: group 1 — low NEOMOD scores (2—4, n=58); group 2 — high NEOMOD scores (≥5, n=20). Inclusion criteria: birth in one perinatal center and immediate admission to ICU, birth weight <1500 grams, gestational age <32 weeks, multiple organ failure within 6 hours of life with NEOMOD score ≥2, dynamic assessment of scores until relief of multiple organ failure or death.

RESULTS

Higher NEOMOD scores were significantly more common in patients with low birth weight (980.0 vs 810.0, p=0.019), lower gestational age (28.0 weeks vs 25.0 weeks, p=0.008) and lower Apgar score at the 1st/5th minutes, respectively (5/6 vs 2.5/5.0, p=0.005/p=0.025). A full course of prenatal steroids avoids severe manifestations of multiple organ failure (46.6% vs 0.0%, p<0.001), and premature rupture of membranes increases the risk of multiple organ failure (17.2% vs 45.0%, p=0.018).

CONCLUSION

The modified NEOMOD score of multiple organ failure in infants with birth weight <1500 grams in early neonatal period increases with lower birth weight, height and gestational age, as well as in premature rupture of membranes. A full course of prenatal steroids has a protective effect against multiple organ failure. Polyuria in premature infants should be regarded as one of the manifestations of multiple organ failure.

Keywords:

multiple organ failure

polyuria

respiratory failure

oliguria

respiratory distress syndrome

Authors:

Karpova A.L.

Vorokhobov Moscow City Clinical Hospital No. 67;
Yaroslavl State Medical University;
Russian Medical Academy for Continuous Professional Education

ORCID: 0000-0002-1024-0230

Mostovoi A.V.

Vorokhobov Moscow City Clinical Hospital No. 67;
Yaroslavl State Medical University;
Russian Medical Academy for Continuous Professional Education

ORCID: 0000-0002-7040-9683

Bagaeva Z.E.

Vorokhobov Moscow City Clinical Hospital No. 67

ORCID: 0000-0001-5237-4440

Soboleva E.Yu.

Vorokhobov Moscow City Clinical Hospital No. 67

ORCID: 0000-0002-0360-4315

Karpov N.Yu.

Tutaevskaya Central Regional Hospital

ORCID: 0000-0001-6728-726X

Karpov L.N.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-4252-4390

Martirosyan S.V.

Vorokhobov Moscow City Clinical Hospital No. 67

ORCID: 0009-0003-8684-9274

Received:

11.10.2023

Accepted:

06.12.2023

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