Место протоколов с антагонистами гонадотропин-рилизинг-гормона в современных программах вспомогательных репродуктивных технологий: возможности использования нового препарата ганиреликса

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Овариальная стимуляция является важнейшим этапом ряда программ вспомогательных репродуктивных технологий (ВРТ), поскольку позволяет получить большую когорту ооцитов в одном менструальном цикле, размер которой напрямую коррелирует с количеством полученных эмбрионов. Одним из приоритетных направлений в репродуктивной медицине является дифференцированный подход к подбору наиболее подходящего протокола стимуляции яичников с учетом возраста пациентки, овариального резерва, наличия сопутствующей генитальной и экстрагенитальной патологии, определяющих прогнозируемый ответ яичников на стимуляцию, с целью получения адекватного количества ооцитов и эмбрионов и снижения риска возможных осложнений. Тенденция к снижению продолжительности овариальной стимуляции, уменьшению медикаментозной нагрузки и, соответственно, стоимости проводимой терапии тесно ассоциирована с повышением удовлетворенности пациенток. Несмотря на то, что долгие годы в качестве «золотого стандарта» лечения бесплодия выступал «длинный» протокол стимуляции с агонистами гонадотропин-рилизинг-гормона, в последние годы в большинстве циклов используются протоколы с антагонистами гонадотропин-рилизинг-гормона. Данный обзор посвящен особенностям использования антагонистов гонадотропин-рилизинг-гормона, в частности ганиреликса, в программах ВРТ, роли этого препарата как в стимулированных циклах, так и в циклах подготовки к переносу размороженного эмбриона.

Ключевые слова:

вспомогательные репродуктивные технологии

агонисты гонадотропин-рилизинг-гормона

антагонисты гонадотропин-рилизинг-гормона

ганиреликс

Авторы:

Денисова Ю.В.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0003-1753-0537

Колода Ю.А.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России;
ООО «Центр репродукции «Линия жизни»

ORCID: 0000-0003-2502-575X

Дата поступления:

15.05.2024

Дата принятия в печать:

06.06.2024

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