Васкулогенная мимикрия

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Применение антиангиогенных препаратов является одним из направлений терапии злокачественных новообразований. Установлено, что развитие феномена васкулогенной мимикрии — специфичного варианта опухолевого неоангиогенеза, формирующегося в высокоагрессивных солидных опухолях, связано со снижением эффективности противоопухолевой терапии. В настоящем обзоре освещены механизмы развития васкулогенной мимикрии при злокачественных новообразованиях, являющейся одним из альтернативных вариантов кровоснабжения опухоли. В формировании васкулогенной мимикрии немаловажная роль отводится опухолевому микроокружению, в первую очередь опухолеассоциированным макрофагам и фибробластам. Охарактеризованы сигнальные пути, регулирующие образование каналов васкулогенной мимикрии в опухолях. Показаны перспективы целенаправленного воздействия на молекулярные мишени, инициирующие и способствующие васкулогенной мимикрии, воздействие на которые может повысить эффективность противоопухолевой терапии. В обзоре обсуждены экспериментальные исследования механизмов формирования васкулогенной мимикрии при злокачественных новообразованиях и перспективы таргетного воздействия на молекулярные мишени — компоненты сигнальных каскадов, участвующих в развитии данной модели неоангиогенеза.

Ключевые слова:

васкулогенная мимикрия

неоангиогенез

меланома

сигнальные пути

микроРНК

Авторы:

Лапкина Е.З.

Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого

ORCID: 0000-0002-7226-9565

Есимбекова А.Р.

Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого

ORCID: 0000-0001-6363-5941

Рукша Т.Г.

ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России

ORCID: 0000-0001-8142-4283

Дата поступления:

05.06.2023

Дата принятия в печать:

12.09.2023

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