Фармакогеномные и фармакометаболомные биомаркеры эффективности и безопасности антидепрессантов: фокус на селективные ингибиторы обратного захвата серотонина

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Эффективность и безопасность психофармакотерапии антидепрессантами имеет большое медицинское значение. Поиск клинических и биологических предикторов для подбора оптимальной психофармакотерапии антидепрессантами активно проводится во всем мире. В основном исследования посвящены поиску ассоциаций полиморфных вариантов генов с эффективностью и безопасностью терапии. Однако информации о генетическом полиморфизме у пациента часто недостаточно, чтобы спрогнозировать эффективность и безопасность лекарственного средства. Современное исследование персонализации фармакотерапии должно включать, помимо генетических, и фенотипические биомаркеры. Это важно, так как генотипирование, например, не может с точностью предсказать реальную метаболическую активность изофермента. Успешное лечение депрессии остается сложной задачей, межиндивидуальные различия в реакции на антидепрессанты являются обычным явлением. Около половины пациентов с депрессивными расстройствами не реагируют на первую попытку терапии антидепрессантами. Серьезные побочные эффекты при фармакотерапии антидепрессантами и прекращение лечения из-за их непереносимости связаны с неэффективностью терапии. В данном обзоре представлены результаты новейших исследований «омиксных» биомаркеров эффективности, безопасности антидепрессантов.

Ключевые слова:

антидепрессанты

фармакогеномика

фармакометаболомика

селективные ингибиторы обратного захвата серотонина

Авторы:

Гареева А.Э.

ФГБНУ «Институт биохимии и генетики» Уфимского Федерального исследовательского центра Российской академии наук;
ФГБОУ ВО «Кемеровский государственный университет»;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0003-0254-3917

Бородина Л.С.

ГБУЗ «Республиканский наркологический диспансер №1» Минздрава Республики Башкортостан

ORCID: 0000-0001-5116-0790

Поздняков С.А.

ГБУЗ города Москвы «Московский научно-практический центр наркологии Департамента здравоохранения города Москвы»

ORCID: 0000-0002-5198-6637

Тимербулатов И.Ф.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России;
ГБУЗ МО «Центральная клиническая психиатрическая больница им. Ф.А. Усольцева»;
ФГБОУ ВО «Российский университет медицины» Минздрава России

ORCID: 0000-0001-5241-6073

Дата поступления:

22.01.2024

Дата принятия в печать:

14.02.2024

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