The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Stanishevskiy A.V.

Kirov Military Medical Academy

Gavrilov G.V.

Kirov Military Medical Academy;
Pavlov First St. Petersburg State Medical University

Lebedenko A.V.

Kirov Military Medical Academy

Adleyba B.G.

Kirov Military Medical Academy

Radkov M.N.

Kirov Military Medical Academy

Svistov D.V.

Kirov Military Medical Academy

Cherebillo V.Yu.

Pavlov First St. Petersburg State Medical University

Intrascopic predictors of favorable outcomes after ventriculoperitoneal shunting in Hakim—Adams syndrome: a single-center retrospective non-randomized study

Authors:

Stanishevskiy A.V., Gavrilov G.V., Lebedenko A.V., Adleyba B.G., Radkov M.N., Svistov D.V., Cherebillo V.Yu.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2024;88(5): 60‑68

DOI: 10.17116/neiro20248805160

Views: 555

Downloaded: 21

Buy PDF (RU) for 200₽
Download PDF (EN)
Contact the author
Table of contents

To cite this article:

Stanishevskiy AV, Gavrilov GV, Lebedenko AV, Adleyba BG, Radkov MN, Svistov DV, Cherebillo VYu. Intrascopic predictors of favorable outcomes after ventriculoperitoneal shunting in Hakim—Adams syndrome: a single-center retrospective non-randomized study. Burdenko's Journal of Neurosurgery. 2024;88(5):60‑68. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20248805160

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Intracardiac migration of a ventriculoperitoneal shunt. A systematic lite­rature review and case report. Burdenko's Journal of Neurosurgery. 2024;(6):88-96
Neuroimaging predictors of favo­rable outcomes after shunting procedures in patients with Hakim—Adams syndrome: a pilot prospective randomized trial. Burdenko's Journal of Neurosurgery. 2025;(1):68-74
The STADHIS stra­tification scale for evaluating the mortality risk in patients with acute limb ischemia following embo­lism. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(2):176-183

The main feature of idiopathic normal pressure hydrocephalus is reversible clinical manifestations after timely ventriculoperitoneal shunting. However, the effectiveness of such interventions does not exceed 85%. Invasive diagnostic methods are used to select candidates for surgery. At the same time, literature data indicate neuroimaging symptoms predicting postoperative outcomes without invasive examination.

OBJECTIVE

To identify intrascopic predictors of favorable outcomes after ventriculoperitoneal shunting in Hakim—Adams syndrome; to present a model for evaluating MRI data and selecting candidates for surgery.

MATERIAL AND METHODS

A single-center retrospective non-randomized study enrolled head MRI data in patients with idiopathic normal-pressure hydrocephalus who underwent ventriculoperitoneal shunting between September 2020 and March 2022. There were 34 patients including 15 ones in the main group (significant improvement after surgery) and 19 ones in the control group. We analyzed quantitative neuroimaging features: ventriculocranial indices, DESH syndrome (DESH score), angle of corpus callosum at the level of anterior and posterior commissures, dimensions of temporal horns of lateral ventricles, the number of lacunar infarcts in basal ganglia and white matter of hemispheres.

RESULTS

We identified the most significant predictors of favorable outcomes after ventriculoperitoneal shunting: Evans index, indexed longitudinal size of lateral ventricles, angle of corpus callosum (at the level of anterior and posterior commissures) and DESH score. We created a classification model using discriminant analysis. This model allows us to predict the outcomes after ventriculoperitoneal shunting.

CONCLUSION

A comprehensive assessment of intrascopic symptoms allows us to predict the outcomes after ventriculoperitoneal shunting in patients with Hakim—Adams syndrome. In the future, we can avoid invasive diagnostic manipulations in some patients.

Keywords:

idiopathic normal pressure hydrocephalus
outcome prediction
callosal angle
DESH syndrome
ventriculoperitoneal shunting

Authors:

Stanishevskiy A.V.

Kirov Military Medical Academy

Gavrilov G.V.

Kirov Military Medical Academy;
Pavlov First St. Petersburg State Medical University

Lebedenko A.V.

Kirov Military Medical Academy

Adleyba B.G.

Kirov Military Medical Academy

Radkov M.N.

Kirov Military Medical Academy

Svistov D.V.

Kirov Military Medical Academy

Cherebillo V.Yu.

Pavlov First St. Petersburg State Medical University

Received:

13.03.2024

Accepted:

21.06.2024

List of references:

  1. Kanno S, Suzuki K. [Preoperative Predictors of Outcomes of Cerebrospinal Fluid Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus]. Brain and Nerves. 2024;76(2):167-173. (In Japanese). https://doi.org/10.11477/mf.1416202579
  2. Guidelines on treatment of normal pressure hydrocephalus of adults. Legzdain MA, Gavrilov GV, Svistov DV, eds. SPb; 2015. (In Russ.).
  3. Toma AK, Papadopoulos MC, Stapleton S, Kitchen ND, Watkins LD. Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. Acta Neurochirurgica. 2013;155(10):1977-1980. https://doi.org/10.1007/s00701-013-1835-5
  4. Greuter L, Schenker T, Guzman R, Soleman J. Endoscopic third ventriculostomy compared to ventriculoperitoneal shunt as treatment for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. British Journal of Neurosurgery. 2022:1-7.  https://doi.org/10.1080/02688697.2022.2149697
  5. Popal AM, Zhu Z, Guo X, Zheng Z, Cai C, Jiang H, Zhang J, Shao A, Zhu J. Outcomes of Ventriculoperitoneal Shunt in Patients With Idiopathic Normal-Pressure Hydrocephalus 2 Years After Surgery. Frontiers in Surgery. 2021;8:641561. https://doi.org/10.3389/fsurg.2021.641561
  6. Torregrossa F, Buscemi F, Gulino V, Campisi BM, Teresi G, Grasso G. Health-Related Quality of Life and Role of Surgical Treatment in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review. World Neurosurgery. 2023;179:197-203.e1.  https://doi.org/10.1016/j.wneu.2023.08.105
  7. Jakopin NE, Myong E, Bogucki T, Gray D, Gross P, McComb JG, Shannon CN, Tamber MS, Toyama M, van der Willigen T, Yazdani A, Hamilton MG, Koschnitzky JE. Establishing ranked priorities for future hydrocephalus research. Journal of Neurosurgery. 2023;139(2):492-501.  https://doi.org/10.3171/2022.10.JNS22753
  8. Nakajima M, Yamada S, Miyajima M, Ishii K, Kuriyama N, Kazui H, Kanemoto H, Suehiro T, Yoshiyama K, Kameda M, Kajimoto Y, Mase M, Murai H, Kita D, Kimura T, Samejima N, Tokuda T, Kaijima M, Akiba C, Kawamura K, Atsuchi M, Hirata Y, Matsumae M, Sasaki M, Yamashita F, Aoki S, Irie R, Miyake H, Kato T, Mori E, Ishikawa M, Date I, Arai H; research committee of idiopathic normal pressure hydrocephalus. Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurologia Medico-Chirurgica. 2021;61(2):63-97.  https://doi.org/10.2176/nmc.st.2020-0292
  9. Thavarajasingam SG, El-Khatib M, Rea M, Russo S, Lemcke J, Al-Nusair L, Vajkoczy P. Clinical predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. Acta Neurochirurgica. 2021;163(10):2641-2672. https://doi.org/10.1007/s00701-021-04922-z
  10. Hong YJ, Kim M-J, Jeong E, Kim J-E, Hwang J, Lee J-I, Lee J-H, Na DL. Preoperative biomarkers in patients with idiopathic normal pressure hydrocephalus showing a favorable shunt surgery outcome. Journal of the Neurological Sciences. 2018;387:21-26.  https://doi.org/10.1016/j.jns.2018.01.017
  11. Kimura T, Yamada S, Sugimura T, Seki T, Miyano M, Fukuda S, Takeuchi S, Miyata S, Tucker A, Fujita T, Hashizume A, Izumi N, Kawasaki K, Nakagaki A, Sako K. Preoperative Predictive Factors of Short-Term Outcome in Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery. 2021;151:e399-e406. https://doi.org/10.1016/j.wneu.2021.04.055
  12. Thavarajasingam SG, El-Khatib M, Vemulapalli K, Iradukunda HAS, K SV, Borchert R, Russo S, Eide PK. Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. Acta Neurochirurgica. 2023;165(2):369-419.  https://doi.org/10.1007/s00701-022-05402-8
  13. Stanishevskiy AV, Gavrilov GV, Radkov MN, Adleyba BG, Svistov DV. Predictors of Satisfactory Surgical Outcome in Idiopathic Normal Pressure Hydrocephalus (Review). Sovremennye tekhnologii v meditsine. 2024;16(2):68.  https://doi.org/10.17691/stm2024.16.2.07
  14. Subramanian HE, Fadel SA, Matouk CC, Zohrabian VM, Mahajan A. The Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery. 2021;149:e1-e10.  https://doi.org/10.1016/j.wneu.2021.02.108
  15. He W, Fang X, Wang X, Gao P, Gao X, Zhou X, Mao R, Hu J, Hua Y, Xia J. A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans’ index. Neuroradiology. 2020;62(6):661-667.  https://doi.org/10.1007/s00234-020-02361-8
  16. Mantovani P, Giannini G, Milletti D, Cevoli S, Valsecchi N, Gramegna LL, Albini-Riccioli L, Sturiale C, Cortelli P, Lanzino G, Elder BD, Palandri G; PRO-HYDRO Study Group. Anterior callosal angle correlates with gait impairment and fall risk in iNPH patients. Acta Neurochirurgica. 2021;163(3):759-766.  https://doi.org/10.1007/s00701-020-04699-7
  17. Shinoda N, Hirai O, Hori S, Mikami K, Bando T, Shimo D, Kuroyama T, Kuramoto Y, Matsumoto M, Ueno Y. Utility of MRI-based disproportionately enlarged subarachnoid space hydrocephalus scoring for predicting prognosis after surgery for idiopathic normal pressure hydrocephalus: clinical research. Journal of Neurosurgery. 2017;127(6):1436-1442. https://doi.org/10.3171/2016.9.JNS161080
  18. Kockum K, Lilja-Lund O, Larsson EM, Rosell M, Söderström L, Virhammar J, Laurell K. The idiopathic normal-pressure hydrocephalus Radscale: a radiological scale for structured evaluation. European Journal of Neurology. 2018;25(3):569-576.  https://doi.org/10.1111/ene.13555
  19. Zemack G, Romner B. Adjustable valves in normal-pressure hydrocephalus: a retrospective study of 218 patients. Neurosurgery. 2002;51:1392-1402.
  20. Bogolepova AN, Vasenina EE, Gomzyakova NA, Gusev EI, Dudchenko NG, Emelin AYu, Zalutskaya NM, Isaev RI, Kotovskaya YuV, Levin OS, Litvinenko IV, Lobzin VYu, Martynov MU, Mkhitaryan EA, Neznanov NG, Palchikova EI, Tkacheva ON, Cherdak MA, Chimagomedova ASh, Yakhno NN. Clinical Guidelines for Cognitive Disorders in Elderly and Older Patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10-3): 6-137. (In Russ.). https://doi.org/10.17116/jnevro2021121103
  21. Virhammar J, Laurell K, Cesarini KG, Larsson EM. The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. Journal of Neurosurgery. 2014;120(1):178-184.  https://doi.org/10.3171/2013.8.JNS13575
  22. Gavrilov GV, Radkov MN, Gydar BV, Svistov DV, Stanishevskiy AV, Averyanov DA. Invasive preoperative diagnostic of idiopathic normal pressure hydrocephalus. Russian Journal of Neurosurgery. 2020;22(1):31-38. (In Russ.). https://doi.org/10.17650/1683-3295-2020-22-1-31-38
  23. Gavrilov GV, Stanishevskiy AV, Gaydar BV, Svistov DV. Idiopathic normal pressure hydrocephalus. Retrospective review of pathogenesis and modern theories. Pathological Physiology and Experimental Therapy, Russian Journal. 2020;64(3):146-155. (In Russ.). https://doi.org/10.25557/0031-2991.2020.03.146-155
  24. Tseng P-H, Huang W-T, Wang J-H, Huang B-R, Huang H-Y, Tsai S-T. Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study. Fluids Barriers CNS. 2024;21(1):16.  https://doi.org/10.1186/s12987-024-00517-9
  25. Andrén K, Wikkelsø C, Laurell K, Kollén L, Hellström P, Tullberg M. Symptoms and signs did not predict outcome after surgery: a prospective study of 143 patients with idiopathic normal pressure hydrocephalus. Journal of Neurology. 2024;271(6):3215-3226. https://doi.org/10.1007/s00415-024-12248-w
  26. Adleyba BG, Gavrilov GV, Stanishevskiy AV, Gaydar BV, Svistov DV, Lobzin VYu, Kolmakova KA. Biomarkers of idiopathic normal pressure hydrocephalus. Nevrologiya, nejrokhirurgiya, psikhosomatika. 2019;11(1):53-58. (In Russ.). https://doi.org/10.14412/2074-2711-2019-1-53-58
  27. Koyama T, Marumoto K, Domen K, Ohmura T, Miyake H. Diffusion tensor imaging of idiopathic normal pressure hydrocephalus: a voxel-based fractional anisotropy study. Neurologia Medico-Chirurgica. 2012;52(2):68-74.  https://doi.org/10.2176/nmc.52.68
  28. Lundin F, Tisell A, Leijon G, Leinhard OD, Davidsson L, Grönqvist A, Wikkelsø C, Lundberg P. Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. Journal of Neurology, Neurosurgery and Psychiatry. 2013;84(2):188-93.  https://doi.org/10.1136/jnnp-2012-302190
  29. Fattahi N, Arani A, Perry A, Meyer F, Manduca A, Glaser K, Senjem ML, Ehman RL, Huston J. MR Elastography Demonstrates Increased Brain Stiffness in Normal Pressure Hydrocephalus. American Journal of Neuroradiology. 2016;37(3):462-7.  https://doi.org/10.3174/ajnr.A4560
  30. Johannsson B, Munthe S, Poulsen FR, Pedersen CB. Idiopathic normal pressure hydrocephalus; treatment and outcome in the Region of Southern Denmark. Clinical Neurology and Neurosurgery. 2022;213:107107. https://doi.org/10.1016/j.clineuro.2021.107107

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.