Неразрешенная проблема: химиоиндуцированная полинейропатия

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Химиоиндуцированная полинейропатия — одна из значимых проблем в современной онкологии, резко ухудшая качество жизни пациентов, зачастую является причиной редукции и даже отмены лекарственной терапии. В обзоре представлены патофизиологические аспекты развития химиоиндуцированной полинейропатии, подробно описаны особенности диагностики лекарственной полинейропатии, факторы риска ее развития, возможности профилактики и лечения. Кроме единственного одобренного на данный момент ASCO дулоксетина, представлены результаты клинических исследований, подтверждающих сопоставимый с дулоксетином лечебный эффект центрального анальгетика со смешанным механизмом действия тапентадола.

Ключевые слова:

химиоиндуцированная полинейропатия

клиника

механизм развития

терапия

тапентадол

Авторы:

Абузарова Г.Р.

Московский научно-исследовательский институт им. П.А. Герцена — филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0002-6146-2706

Сарманаева Р.Р.

ORCID: 0000-0002-0727-5758

Германова О.В.

Московский научно-исследовательский институт им. П.А. Герцена — филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России

Дата поступления:

10.09.2024

Дата принятия в печать:

13.09.2024

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