Метаболический синдром и антипсихотическая терапия шизофрении

Закрыть метаданные

В статье обсуждаются вопросы связи метаболических нарушений с шизофренией и антипсихотической терапией, а также значение метаболического синдрома для здоровья пациентов с шизофренией. Рассматриваются факторы риска развития метаболического синдрома. Дается характеристика метаболическим побочным эффектам различных антипсихотиков. Описываются варианты терапевтической тактики при развитии метаболического синдрома на фоне антипсихотической терапии.

Ключевые слова:

шизофрения

метаболический синдром

антипсихотики

Авторы:

Петрова Н.Н.

ФГБОУ ВО «Санкт-Петербургский государственный университет»

ORCID: 0000-0003-4096-6208

Семенова Н.В.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России

ORCID: 0000-0002-2798-8800

Дата поступления:

16.10.2024

Дата принятия в печать:

17.10.2024

Список литературы:

Crump C, Winkleby MA, Sundquist K, et al. Comorbidities and mortality in persons with schizophrenia: A Swedish national cohort study. American Journal of Psychiatry. 2013;170(3):324-333. https://doi.org/10.1176/appi.ajp.2012.12050599
Hjorthøj C, Stürup AE, McGrath JJ, et al. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry. 2017;4(4):295-301. https://doi.org/10.1016/S2215-0366(17)30078-0
Correll CU, Solmi M, Veronese N, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 2017;16(2):163-180. https://doi.org/10.1002/wps.20420
Osby U, Correia N, Brandt L, et al. Mortality and causes of death in schizophrenia in Stockholm County, Sweden. Schizophrenia Research. 2000;45(1-2):21-28. https://doi.org/10.1016/s0920-9964(99)00191-7
Pillinger T, Osimo EF, de Marvao A, et al. Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: An MRI study. Translational Psychiatry. 2019;9(1):163. https://doi.org/10.1038/s41398-019-0502-x
Mitchell AJ, Vancampfort D, Sweers K, et al. Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders-a systematic review and meta-analysis. Schizophrenia Bulletin. 2013;39(2):306-318. https://doi.org/10.1093/schbul/sbr148
De Hert M, Detraux J, van Winkel R, et al. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nature Reviews Endocrinology. 2011;8(2):114-126. https://doi.org/10.1038/nrendo.2011.156
Greenhalgh AM, Gonzalez-Blanco L, Garcia-Rizo C, et al. Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naive patients with nonaffective psychosis. Schizophrenia Research. 2017;179:57-63. https://doi.org/10.1016/j.schres.2016.09.026
Pillinger T, Beck K, Gobjila C, et al. Impaired glucose homeostasis in first-episode schizophrenia: A systematic review and meta-analysis. JAMA Psychiatry. 2017a;74(3):261-269. https://doi.org/10.1001/jamapsychiatry.2016.3803
Pillinger T, Beck K, Stubbs B, et al. Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis. British Journal of Psychiatry. 2017;211(6):339-349. https://doi.org/10.1192/bjp.bp.117.200907
Vancampfort D, Wampers M, Mitchell AJ, et al. A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls. World Psychiatry. 2013;12(3):240-250. https://doi.org/10.1002/wps.20069
Pillinger T, McCutcheon RA, Vano L, et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7(1):64-77. https://doi.org/10.1016/S2215-0366(19)30416-X
Pillinger T, McCutcheon RA, Howes OD. Variability of glucose, insulin, and lipid disturbances in first-episode psychosis: a meta-analysis. Psychological Medicine. 2023;53(7):3150-3156. https://doi.org/10.1017/S0033291721005213
Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382:951-962. https://doi.org/10.1016/S0140-6736(13)60733-3
Kishimoto T, Hagi K, Nitta M, et al. Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons. World Psychiatry. 2019;18:208-224. https://doi.org/10.1002/wps.20632
Bessonova L, Velligan DI, Weiden PJ, et al. Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey. BMC Psychiatry. 2020;20:354. https://doi.org/10.1186/s12888-020-02767-x
Doane MJ, Sajatovic M, Weiden PJ, et al. Antipsychotic treatment experiences of people with schizophrenia: patient perspectives from an online survey. Patient Preference and Adherence. 2020;14:2043-2054. https://doi.org/10.2147/PPA.S270020.
Solmi M, Murru A, Pacchiarotti I, et al. Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review. Therapeutics and Clinical Risk Management. 2017;13:757-777. https://doi.org/10.2147/TCRM.S117321
Newcomer JW, Haupt DW, Fucetola R, et al. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Archives of general psychiatry. 2002;59(4):337-345. https://doi.org/10.1001/archpsyc.59.4.337
Patel JK, Buckley PF, Woolson S, et al. CAFE Investigators. Metabolic profiles of second generation antipsychotics in early psychosis: findings from the CAFE study. Schizophrenia Research. 2009;111:9-16. https://doi.org/10.1016/j.schres.2009.03.025
Saddichha S, Manjunatha N, Ameen S, et al. Metabolic syndrome in first episode schizophrenia — a randomized doubleLblind controlled, shortLterm prospective study. Schizophrenia Research. 2008;101(1-3):266-272. https://doi.org/10.1016/j.schres.2008.01.004
Doane MJ, Bessonova L, Friedler HS, et al. Weight gain and comorbidities associated with oral second-generation antipsychotics: analysis of real-world data for patients with schizophrenia or bipolar I disorder. BMC Psychiatry. 2022;22(1):114. https://doi.org/10.1186/s12888-022-03758-w
Goeb JL, Marco S, Duhamel A, et al. Metabolic side effects of risperidone in early onset schizophrenia. Encephale. 2010;36(3):242-252. https://doi.org/10.1016/j.encep.2009.10.008
Lee AK, Bishop JR. Pharmacogenetics of leptin in antipsychoticLassociated weight gain and obesityLrelated complications. Pharmacogenomics. 2011;12(7):999-1016. https://doi.org/10.2217/pgs.11.45
Алфимов П.В., Рывкин П.В., Ладыженский М.Я. и др. Метаболический синдром у больных шизофренией (обзор литературы). Современная терапия психических расстройств. 2014;3:8-14.
Carli M, Kolachalam S, Longoni B, et al. Atypical Antipsychotics and Metabolic Syndrome: From Molecular Mechanisms to Clinical Differences. Pharmaceuticals (Basel). 2021;14(3):238. https://doi.org/10.3390/ph14030238
Molina JD, Avila S, Rubio G, et al. Metabolomic Connections between Schizophrenia, Antipsychotic Drugs and Metabolic Syndrome: A Variety of Players. Current Pharmaceutical Design. 2021;27(39):4049-4061. https://doi.org/10.2174/1381612827666210804110139
Finkel B, Goodman C, Melamed Y, et al. Differences in metabolic side-effects of typical and atypical antipsychotic treatment in elderly individuals with long-term schizophrenia. Hong Kong Journal of Psychiatry, 2009;19(3):103-106.
Ho CS, Zhang MW, Mak A, et al. Metabolic syndrome in psychiatry: advances in understanding and management. Advances in Psychiatric Treatment. 2014;20:101-112.
Popovic I, Ravanic D, Djukic-Dejanovic S, et al. Prevalence and predictors of the metabolic syndrome in patients on the long term atypical antipsychotic treatment. European Neuropsychopharmacology. 2015;25(2):490. https://doi.org/10.1016/S0924-977X(15)30669-6
Yu L, Wu S, Deng Y, et al. Insulin resistance induced by olanzapine and other second-generation antipsychotics in Chinese patients with schizophrenia: a comparative review and meta-analysis. European Journal of Clinical Pharmacology. 2019;75(12):1621-1629. https://doi.org/10.1007/s00228-019-02739-5
Galling B, Roldán A, Rietschel L, et al. Safety and tolerability of antipsychotic co-treatment in patients with schizophrenia: results from a systematic review and meta-analysis of randomized controlled trials. Expert Opinion on Drug Safety. 2016;15(5):591-612. https://doi.org/10.1517/14740338.2016.1165668
Gallego JA, Nielsen J, De Hert M, et al. Safety and tolerability of antipsychotic polypharmacy. Expert Opinion on Drug Safety. 2012;11(4):527-542. https://doi.org/10.1517/14740338.2012.683523
Chang JS, Ahn YM, Park HJ, et al. Aripiprazole augmentation in clozapine-treated patients with refractory schizophrenia: an 8-week, randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry. 2008;69(5):720-731. https://doi.org/10.4088/jcp.v69n0505
Fan X, Borba CP, Copeland P, et al. Metabolic effects of adjunctive aripiprazole in clozapine-treated patients with schizophrenia. Acta Psychiatrica Scandinavica. 2013;127(3):217-226. https://doi.org/10.1111/acps.12009
Fleischhacker WW, Heikkinen ME, Olié JP, et al. Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. International Journal of Neuropsychopharmacology. 2010;13(8):1115-1125. https://doi.org/10.1017/S1461145710000490
Srisurapanont M, Suttajit S, Maneeton N, et al. Efficacy and safety of aripiprazole augmentation of clozapine in schizophrenia: a systematic review and meta-analysis of randomized-controlled trials. Journal of Psychiatric Research. 2015;62:38-47. https://doi.org/10.1016/j.jpsychires.2015.01.004
Henderson DC, Fan X, Copeland PM, et al. Aripiprazole added to overweight and obese olanzapine-treated schizophrenia patients. Journal of Clinical Psychopharmacology. 2009;29(2):165-169. https://doi.org/10.1097/JCP.0b013e31819a8dbe
Newcomer JW, Campos JA, Marcus RN, et al. A multicenter, randomized, double-blind study of the effects of aripiprazole in overweight subjects with schizophrenia or schizoaffective disorder switched from olanzapine. Journal of Clinical Psychiatry. 2008;69:1046-1056.
Stroup TS, Byerly MJ, Nasrallah HA, et al. Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: results from a randomized controlled trial. Schizophrenia Research. 2013;146(1-3):190-195. https://doi.org/10.1016/j.schres.2013.01.013
Mizuno Y, Suzuki T, Nakagawa A, et al. Pharmacological strategies to counteract antipsychotic-induced weight gain and metabolic adverse effects in schizophrenia: a systematic review and meta-analysis. Schizophrenia Bulletin. 2014;40(6):1385-1403. https://doi.org/10.1093/schbul/sbu030

Закрыть метаданные