Генетические варианты, ассоциированные с развитием стрессовых расстройств по данным GWAS

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Изучение генетических основ посттравматического стрессового расстройства (ПТСР) может быть полезно для прогнозирования риска его развития у человека, пережившего сильный травматический стресс, и способствовать более раннему выявлению проблемы и обращению к специалисту. Целью работы был обзор всех исследований GWAS, касающихся ПТСР. Всего включено 20 исследований, из них 5 метаанализов, 9 проведены на ветеранах войн. Рассмотрены функции генов и их ассоциации, которые включали в себя однуклеотидные полиморфизмы в разных группах генов, участвующих в эмбриогенезе, формировании нейронов, функционировании клетки, а также множество последовательностей ДНК, на которых транскрибируется некодирующая РНК. Изучена повторяемость полученных результатов между исследованиями и на репликативных выборках. Между исследованиями ассоциации повторились в генах CAMKV, CDHR4, DCC, FAM120A, FOXP2 (3 работы), MAD1L1 (3 работы), MAPT, NCAM1, NOS1, SP4, ZMYM4, TCF4. Отдельно рассмотрено новое и масштабное исследование с множеством обнаруженных ассоциаций. Изучены работы относительно полигенного риска, который показал генетическую коморбидность с тревогой и биполярным расстройством более чем в одной работе. Однако разработанные авторами модели объясняют малый процент дисперсии и слабо повторяются на других выборках. Вероятно, решить эту проблему можно, используя большие выборки и более четкие однородные критерии включения. Таким образом, на настоящий момент исследований GWAS ПТСР мало, они неоднозначны и малоинформативны по сравнению с такими же исследованиями для других психических расстройств, однако имеют дальнейший потенциал для оценки рисков развития болезни.

Ключевые слова:

GWAS

ПТСР

стресс

полигенный риск

Авторы:

Зоркина Я.А.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии В.П. Сербского» Минздрава России;
ГБУЗ «Психиатрическая клиническая больница №1 им. Н.А. Алексеева Департамента здравоохранения Москвы»

ORCID: 0000-0003-0247-2717

Голубева Е.А.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии В.П. Сербского» Минздрава России

ORCID: 0009-0003-4024-5184

Гурина О.И.

ORCID: 0000-0001-6942-5531

Резник А.М.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии В.П. Сербского» Минздрава России;
ФГБОУ ВО «Российский биотехнологический университет»

ORCID: 0000-0002-7076-5901

Морозова А.Ю.

ORCID: 0000-0002-8681-5299

Дата поступления:

12.07.2024

Дата принятия в печать:

23.10.2024

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