E-кадгерин: строение и функции, роль в канцерогенезе рака желудка

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Обзор посвящен E-кадгерину — кальцийзависимой молекуле межклеточной адгезии, играющей ключевую роль в поведении клеток, формировании тканей и канцерогенезе. В обзоре приведены данные о строении E-кадгерина, его роли в развитии организма и в процессах канцерогенеза. Подробно описано строение E-кадгерин/β-катенин/αE-катенинового комплекса и его связь с актиновым цитоскелетом. Освещены роль E-кадгерина в развитии некоторых инфекционных заболеваний, функции E-кадгерина как опухолевого супрессора, так и промотора опухолевой диссеминации, его влияние на пути передачи сигнала в клетках. Особое внимание уделено экспрессии E-кадгерина при инфекции Helicobacter pylori и в опухолевой ткани при раке желудка.

Ключевые слова:

E-кадгерин

рак желудка

Helicobacter pylori

канцерогенез

опухолевая прогрессия

опухолевые эмболы

кадгерины

катенины

Авторы:

Данилова Н.В.

ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»

SPIN РИНЦ: 6878-2025
Scopus AuthorID: 36613033400
ResearcherID: H-6477-2014
ORCID: 0000-0001-7848-6707

Олейникова Н.А.

ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»

SPIN РИНЦ: 4076-2637
Scopus AuthorID: 57193513523
ResearcherID: H-7672-2014
ORCID: 0000-0001-8564-8874

Дата поступления:

10.01.2023

Дата принятия в печать:

19.04.2023

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