Cellular and molecular factors of innate immunity in the pathogenesis of external genital endometriosis in women (a review)

Close metadata

Recommended articles:

Deubiquitinase and unconjugated ubiquitin activate microenvironment inflammation and pain in eutopic and ectopic endometrium in endometriosis. Russian Journal of Human Reproduction. 2023;(1):9-18

Features of the relationship between the subpopulation composition and the content of cytokines in the peripheral blood and peritoneal fluid of women with endometriosis. Russian Journal of Human Reproduction. 2023;(1):19-32

Agonists of gonadotropin-releasing-hormone and add-back-therapy. Russian Bulletin of Obstetrician-Gynecologist. 2023;(2):63-69

Keratoconus: main lines of research. Russian Annals of Ophthalmology. 2023;(3):11-20

Evaluation of the effectiveness of dienogest in the treatment of chronic pelvic pain in patients with endometriosis. Russian Journal of Human Reproduction. 2023;(2):51-56

Endometriosis-associated pain and adhesions — new pathogenetic aspects and therapeutic approach. Russian Journal of Human Reproduction. 2023;(2):93-100

Cause-effect factors of rhinosinusitis poliposa development. Russian Rhinology. 2023;(2):124-130

Acute limb ischemia in patients with COVID-19. Russian Journal of Cardiology and Cardiovascular Surgery. 2023;(3):267-271

Clinical observation of incomplete uterine rupture after combined treatment of infiltrative endometriosis and uterine myoma using self-fixing suture material V-Loc in myorrhaphy. Russian Bulletin of Obstetrician-Gynecologist. 2023;(3):105-109

Opportunities to improve the effectiveness of complex therapy for endometriosis and chronic pelvic pain in patients of reproductive age. Russian Journal of Human Reproduction. 2023;(3):91-97

ABSTRACT Literature data analysis of the role of cellular and humoral factors of inborn immunity in the pathogenesis of endometriosis is presented. Review includes the data from foreign and domestic articles for a research topic, published in the Pubmed database journals over the past 15 years. The data about contribution of cellular and humoral factors of inborn immunity acting at the local and systemic level to the pathogenesis of endometriosis are presented. Given the polyfunctionality of cells and cytokines which are the pleiotropic proteins with significant redundancy of functions, it is still difficult to determine how they affect the pathogenesis of endometriosis. The factors of inborn immunity are the significant ones in the development of endometrioid lesions. The presented data expand the knowledge of pathogenesis of endometriosis and indicate to the need for further study of the role of these factors. A deeper understanding of their mechanisms can help to improve the management of the women with external genital endometriosis and the possibility of targeted therapy application, including the influence to the factors of inborn immunity.

Keywords:

endometriosis

pathogenesis

immune dysfunction

factors of inborn immunity

Authors:

T.D. Korotkova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russia, Moscow, Russia

L.V. Adamyan

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

A.A. Stepanian

Kafedpa peppoduktivnoĭ meditsiny i xipupgii Mockovckogo univepciteta meditsiny i ctomatologii

L.V. Krechetova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russia, Moscow, Russia

L.V. Vanko

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russia, Moscow, Russia

List of references:

Adamyan LV, Kulakov VI, Andreeva EN. Ehndometriozy. M.: Medicina; 2006. (In Russ.)
Adamyan LV, Andreeva EN. The role of modern hormone-modulating therapy in the complex treatment of genital endometriosis. Problemy reproduktsii. 2011;6:66-77. (In Russ.)
Koninckx PR, Ussia A, Keckstein J, Wattiez A, Adamyan L. Epidemiology of subtle, typical, cystic, and deep endometriosis: a systematic review. Gynecological Surgery. 2016;13(4):457-467. https://doi.org/10.1007/s10397-016-0970-4
Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Annals of the New York Academy of Sciences. 2008;1127:106-115. https://doi.org/10.1196/annals.1434.014
Sotnikova NYu, Antsiferova YuS, Posiseeva LV, Shor AL, Bragin BI. Features of systemic and local immune response in women with various forms of endometriosis. Immunologiya. 2003;4:242-245. (In Russ.)
Sukhikh GT, Sotnikova NYu, Antsiferova YuS, Posiseeva LV, Veryasov VN, Vanko LV. Production of cytokines by immunocompetent cells of peritoneal fluid in women with external genital endometriosis. Byulleten’ ehksperimental’noj biologii i mediciny. 2004;137(6):569-571. (In Russ.)
Antsiferova YuS, Sotnikova NYu, Posiseeva LV, Nazarov SB. Immunnye mekhanizmy razvitiya genital’nogo ehndometrioza. Ivanovo. 2007. (In Russ.)
Swann JB, Smyth MJ. Immune surveillance of tumors. Journal of Clinical Investigation. 2007;117(5):1137-1146. https://doi.org/10.1172/JCI31405
Yarmolinskaya MI. Cytokine profile of peritoneal fluid and peripheral blood of patients with external genital endometriosis. Zhurnal akusherstva i zhenskih boleznej. 2008;57(3):30-34. (In Russ.)
Sourial S, Tempest N, Hapangama DK. Theories on the pathogenesis of endometriosis. International Journal of Reproductive Medicine. 2014;2014:179515. https://doi.org/10.1155/2014/179515
Gilabert-Estelles J, Estelles A, Gilabert J, Castello R, Espana F, Falco C. Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis. Human Reproduction. 2003;18:1516-1522.
May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Human Reproduction Update. 2011;17(5):637-653. https://doi.org/10.1093/humupd/dmr013.dmr013
Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R, Tayade C. Pathophysiology and immune dysfunction in endometriosis. BioMed Research International. 2015;2015:795976. https://doi.org/10.1155/2015/795976
Kobayashi H, Higashiura Y, Higetomi HH, Kajihara H. Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation (Review). Molecular Medicine Reports. 2014;9:9-15.
Terakawa N, Harada T. The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis. Human Reproduction. 2009;24:3172-3179.
Reis FM, Petraglia F, Taylor RN. Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Human Reproduction Update. 2013;19(4):406-418.
Rosales C. Neutrophil. A cell with many roles in inflammation or several cell types? Frontiers in Physiology. 2018;9:113. https://doi.org/10.3389/fphys.2018.00113
Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016;127(18):2173-2181. https://doi.org/10.1182/blood-2016-01-688887
Nesterova IV, Kolesnikova NV, Chudilova GA, Lomtatidze LV, Kovaleva SV, Evglewski AA, Nguen TZL. A new look at neutrophilic granulocytes. Rethinking old dogmas. Part 1. Infekciya i immunitet. 2017;7(3):219-230. (In Russ.)
Selders GS, Fetz AE, Radic MZ, Bowlin GL. An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration. Regenerative Biomaterials. 2017;4(1):55-68. https://doi.org/10.1093/rb/rbw041
Bacci M, Capobianco A, Monno A, Cottone L, Di Puppo F, Camisa B, Mariani M, Brignole C, Ponzoni M, Ferrari S, Panina-Bordignon P, Manfredi AA, Rovere-Querini P. Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease. The American Journal of Pathology. 2009;175(2):547-556. https://doi.org/10.2353/ajpath.2009.081011
Yeo SG, Won YS, Lee HY, Kim YI, Lee JW, Park DC. Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis. International Journal of Medical Sciences. 2013;10(9):1199-1208. https://doi.org/10.7150/ijms.5169
Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y. Lymphocytes in endometriosis. American Journal of Reproductive Immunology. 2011;65(1):1-10. https://doi.org/10.1111/j.1600-0897.2010.00887
Sikora J, Mielczarek-Palacz A, Kondera-Anasz Z. Role of Natural Killer cell activity in the pathogenesis of endometriosis. Current Medicinal Chemistry. 2011;18(2):200-208. https://doi.org/10.2174/092986711794088416
Jeung I, Cheon K, Kim MR. Decreased cytotoxicity of peripheral and peritoneal natural killer cell in endometriosis. BioMed Research International. 2016;2016:2916070. https://doi.org/10.1155/2016/2916070
Schulke L, Berbic M, Manconi F, Tokushige N, Markham R, Fraser IS. Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis. Human Reproduction. 2009;24(7):1695-1703. https://doi.org/10.1093/humrep/dep071
Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Endometriosis: molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science Translational Medicine. 2014;6(222): 222ra16. https://doi.org/10.1126/scitranslmed.3007988.222ra16
Capobianco A, Rovere-Querini P. Endometriosis, a disease of the macrophage. Frontiers in Immunology. 2013;28:4-9. https://doi.org/10.3389/fimmu.2013.00009
Na Y-J, Jin J-O, Lee M-S, Song M-G, Lee K-S, Kwak J-Y. Peritoneal fluid from endometriosis patients switches differentiation of monocytes from dendritic cells to macrophages. Journal of Reproductive Immunology. 2008;77(1):63-74. https://doi.org/10.1016/j.jri.2007.03.013
Kalu E, Sumar N, Giannopoulos T, Patel P, Croucher C, Sherriff E, Bansal A. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. Journal of Obstetrics and Gynaecology Research. 2007;33(4):490-495. https://doi.org/10.1111/j.1447-0756.2007.00569.x
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z. Abnormal peritoneal regulation of chemokine activation — the role of IL-8 in pathogenesis of endometriosis. American Journal of Reproductive Immunology. 2017;77(4). https://doi.org/10.1111/aji.12622
Li A, Dubey S, Varney ML, Dave BJ, Singh RK. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. Journal of Immunology. 2003;170(6):3369-3376. https://doi.org/10.4049/jimmunol.170.6.3369
Borrelli GM, Kaufmann AM, Abrão MS, Mechsner S. Addition of MCP-1 and MIP-3β to the IL-8 appraisal in peritoneal fluid enhances the probability of identifying women with endometriosis. Journal of Reproductive Immunology. 2015;109:66-73. https://doi.org/10.1016/j.jri.2015.01.003
Wu MH, Lu CW, Chuang PC, Tsai SJ. Prostaglandin E₂: the master of endometriosis? Experimental Biology and Medicine. 2010;235(6):668-677. https://doi.org/10.1258/ebm.2010.009321
Okamura H, Koyama K. Role of IL-18 in pathogenesis of endometriosis. Human Reproduction. 2004;19:709-714.
Cameron MJ, Kelvin DJ. Cytokines and chemokines — their receptors and their genes: an overview. Advances in Experimental Medicine and Biology. 2003;520:8-32. https://doi.org/10.1007/978-1-4615-0171-82
Gogacz M, Winkler I, Bojarska-Junak A, Tabarkiewicz J, Semczuk A, Rechberger T, Adamiak A. Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis. Journal of Reproductive Immunology. 2016;117:39-44. https://doi.org/10.1016/j.jri.2016.04.289
Ahn SH, Edwards AK, Singh SS, Young SL, Lessey BA, Tayade C. il-17a contributes to the pathogenesis of endometriosis by triggering proinflammatory cytokines and angiogenic growth factors. Journal of Immunology. 2015;(6):2591-2600. https://doi.org/10.4049/jimmunol.1501138
Kang YJ, Jeung IC, Park A, Park YJ, Jung H, Kim TD, Lee HG, Choi I, Yoon SR. An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression. Human Reproduction. 2014;29(10):2176-2189. https://doi.org/10.1093/humrep/deu172
Suen JL, Chang Y, Chiu PR, Hsieh TH, Hsi E, Chen YC, Chen YF, Tsai EM. Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model. American Journal of Pathology. 2014;184(2):464-471. https://doi.org/10.1016/j.ajpath.2013.10.023
Young VJ, Brown JK, Saunders PT, Duncan WC, Horne AW. The peritoneum is both a source and target of TGF-β in women with endometriosis. PLoS One. 2014;9(9):e106773. https://doi.org/10.1371/journal.pone.0106773
Hull ML, Johan MZ, Hodge WL, Robertson SA, Ingman WV. Host-derived TGFβ1 deficiency suppresses lesion development in a mouse model of endometriosis. American Journal of Pathology. 2012;180:880-887.
Saito A, Osuga Y, Yoshino O, Takamura M, Hirata T, Hirota Y, Koga K, Harada M, Takemura Y, Yano T, Taketani Y. TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6. Human Reproduction. 2011;26(7):1892-1898. https://doi.org/10.1093/humrep/der125
Yu YX, Xiu YL, Chen X, Li YL. Transforming Growth Factor- beta 1 involved in the pathogenesis of endometriosis through regulating expression of Vascular Endothelial Growth Factor under hypoxia. Chinese Medical Journal. 2017;130(8):950-956. https://doi.org/10.4103/0366-6999.204112
Young VJ, Ahmad SF, Duncan WC, Horne AW.The role of TGF-β in the pathophysiology of peritoneal endometriosis. Human Reproduction Update. 2017;23(5):548-559. https://doi.org/10.1093/humupd/dmx016
Nasu K, Nishida M, Kawano Y, Tsuno A, Abe W, Yuge A, Takai N, Narahara H. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reproductive Sciences. 2011;18(3):206-218. https://doi.org/10.1177/1933719110392059
Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M. Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis. Fertility and Sterility. 2010;94:52-57.
Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, Lessey BA, Tayade C. Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients. Fertility and Sterility. 2016;105(4):968-977. https://doi.org/10.1016/j.fertnstert.2015.11.047
Muñoz-Hernando L, Muñoz-Gonzalez JL, Marqueta-Marques L, Alvarez-Conejo C, Tejerizo-García Á, Lopez-Gonzalez G, Villegas-Muñoz E, Martin-Jimenez A, Jiménez-López JS. Endometriosis: alternative methods of medical treatment. International Journal of Women’s Health. 2015;7:595-603. https://doi.org/10.2147/IJWH.S78829

Close metadata