Комплексное влияние полифенолов на микробиом кишечника и пусковые механизмы нейродегенерации при болезни Паркинсона

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Кишечная дисфункция и изменение микробиома активно обсуждаются в современной литературе как важнейшее звено развития нейродегенеративных изменений при болезни Паркинсона. В статье рассматривается патогенетическая цепочка микробиом-кишечник-мозг, а также факторы, которые влияют на развитие кишечного дисбиоза. Перспективным направлением воздействия на микрофлору и воспалительные изменения в кишечнике является применение полифенолов, прежде всего куркумина. Приводится обзор экспериментальных, лабораторных, клинических исследований, доказывающих плейотропный эффект куркумина — его антиоксидантное, противоспатилительное, нейропротективное действие, реализующееся через как периферические, так и центральные механизмы.

Ключевые слова:

болезнь Паркинсона

кишечная дисфункция

микробиом

полифенолы

куркумин

Авторы:

Катунина Е.А.

ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства России;
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России

ORCID: 0000-0001-5805-486X

Семенова А.М.

ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства России

ORCID: 0000-0002-3880-9345

Катунин Д.А.

ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства России

ORCID: 0000-0002-4109-8935

Дата поступления:

08.09.2023

Дата принятия в печать:

12.09.2023

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