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Grechko A.V.

Negovsky Research Institute of Intensive Care

Gurkova M.M.

Research Production Center «MicroMir»

Zhdanova M.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Zurabov A.Yu.

Research Production Center «MicroMir»

Zurabov F.M.

Research Production Center «MicroMir»

Kuzovlev A.N.

Negovsky Research Institute of Intensive Care

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Polyakov P.A.

Federal Research Clinical Center for Intensive Care and Rehabilitation

Cheboksarov D.V.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Chernevskaya E.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yuryev M.Yu.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yakovlev A.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Prevention of nosocomial pneumonia recurrence using a bacteriophage cocktail in intensive care unit

Authors:

Grechko A.V., Gurkova M.M., Zhdanova M.A., Zurabov A.Yu., Zurabov F.M., Kuzovlev A.N., Petrova M.V., Polyakov P.A., Cheboksarov D.V., Chernevskaya E.A., Yuryev M.Yu., Yakovlev A.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(2): 39‑48

DOI: 10.17116/anaesthesiology202402139

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To cite this article:

Grechko AV, Gurkova MM, Zhdanova MA, et al. . Prevention of nosocomial pneumonia recurrence using a bacteriophage cocktail in intensive care unit. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):39‑48. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202402139

Подписка 2025-2 (АиР)
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Chronically critically ill patients are a rapidly growing population requiring long-term intensive care. Lower respiratory tract infections are the main infectious complications in these patients. Adaptive phage prophylaxis may be one of the perspective and insufficiently studied approaches for prevention of respiratory infectious complications in intensive care units.

OBJECTIVE

To study the effectiveness of complex cocktail complex drag of bacteriophages in prevention of infectious respiratory complications in chronically critically ill patients.

MATERIAL AND METHODS

The study included ICU patients at the Federal Research Clinical Center of Intensive Care and Rehabilitology. Overall sample consisted of 79 patients with severe brain damage. Group 1 (n=41) received complex drag of bacteriophages for prevention of pneumonia, group No. 2 (n=38) — standard therapy. All patients were followed-up for 28 days.

RESULTS

Both groups were comparable in gender, age and clinical severity. Microbiological examination revealed multidrug-resistant gram-negative bacteria (Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) in majority of patients. In the 1st group, resistance genes were less common compared to the control group. Incidence of recurrent pneumonia was lower in the same group.

CONCLUSION

Prophylactic phage therapy can reduce the number of antimicrobial drugs. Incidence of nosocomial pneumonia recurrences after 14 and 21 days was lower in the main group.

Keywords:

antibiotics
resistance
pneumonia
phage prophylaxis

Authors:

Grechko A.V.

Negovsky Research Institute of Intensive Care

Gurkova M.M.

Research Production Center «MicroMir»

Zhdanova M.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Zurabov A.Yu.

Research Production Center «MicroMir»

Zurabov F.M.

Research Production Center «MicroMir»

Kuzovlev A.N.

Negovsky Research Institute of Intensive Care

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Polyakov P.A.

Federal Research Clinical Center for Intensive Care and Rehabilitation

Cheboksarov D.V.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Chernevskaya E.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yuryev M.Yu.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yakovlev A.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Received:

11.10.2023

Accepted:

06.12.2023

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